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- This Supplement mimics Anti-Arthritis Benefits of a Ketogenic Diet, without the Diet
This Supplement mimics Anti-Arthritis Benefits of a Ketogenic Diet, without the Diet
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0:00 - Introduction
0:55 - Ketosis and Arthritis
2:21 - The Study
3:50 - Arthritis Relief?
5:00 - A Twist in the Story...
7:25 - I Disagree with the Researchers
9:21 - Main Points
Reference
[Study 458] Heidt C, Pons-Kühnemann J, Kämmerer U, Marquardt T, Reuss-Borst M. MCT-Induced Ketosis and Fiber in Rheumatoid Arthritis (MIKARA)-Study Protocol and Primary Endpoint Results of the Double-Blind Randomized Controlled Intervention Study Indicating Effects on Disease Activity in RA Patients. Nutrients. 2023;15(17):3719. Published 2023 Aug 25. doi:10.3390/nu15173719
Funding/Conflicts: Industry [Schär AG/SPA] // Potential direct Conflicts of Interest [One researcher is employed by the company]
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#rheumatoidarthritis #arthritisrelief
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Video Transcript
What if you could improve your arthritis pain without having to change your diet,
but still mimicking an arthritis-improving diet?
There's some evidence that low-carbohydrate diets,
especially those that increase ketones, a molecule produced by your liver,
can improve arthritis.
But adopting a very low-carbohydrate diet that raises ketones enough is tough for some.
That's because the lower your carbohydrate intake, the greater your ketone levels, generally.
Fortunately, there's an easy solution.
Let's get into it.
The believed reason for why the ketogenic diet leads to arthritis benefits is because
of these aforementioned ketones.
They're molecules that
your liver produces when there's insufficient carbohydrate or glucose entering the liver.
It's an alternate fuel source for many of your cells, and yet more research indicates
that they can be more than just nutrients to your cells.
In this case, arthritis.
Ketones reduce the production of inflammatory molecules from your cells, which is especially
powerful in rheumatoid arthritis, which is characterized primarily by increased inflammation
in the body leading to the destruction of the joint structure in the body by the immune cells.
Reducing inflammation means reducing these activated destructive cells
and alleviating the insult to the joint structure.
Since ketones reduce the expression of certain inflammatory molecules like cytokines,
interleukin-1 beta, interleukin-6, interleukin-18,
that activate these immune cells, it makes sense to focus on the ketones.
There's a ton on the mechanisms that I'll cover in more detail in other content, but
generally this is the thought process for why a ketogenic diet that encourages ketone
production would have this beneficial arthritis effect.
Still, like we discussed before, it's not feasible for everyone, and even if it is,
wouldn't it be nice to ensure your ketone levels stay elevated even if you were to accidentally
slip and fall and your mouth lands on a cookie and accidentally chews it multiple times before
swallowing it. Happens all the time. The National Bureau of BS Statistics indicates it happens
100% in certain households, so this isn't theoretical.
OK, how do we pick our cookie and eat it too? By accident, of course. That's where this
study comes in. The researchers randomly assigned men and women with rheumatoid arthritis to
consume their usual diet. But supplement with a medium-chain triglyceride supplement or
or a long chain triglyceride supplement. I'll explain what those are in a second. And participants
were instructed to consume each supplement every day for 16 weeks, with a major caveat
that we'll get into.
The medium chain triglycerides and long chain triglycerides are simply different sized fat
molecules. One contains 6 to 12 carbons linked together, and the other contains 13 to 21
carbons. I'll let you figure out which is which.
MCTs, or medium-chain triglycerides, are more easily absorbed by the liver and can therefore
be easily converted to ketones.
LCTs, or long-chain triglycerides, are not as readily converted.
So you can imagine.
Imagine that the MCT group experienced an increase in ketones, right?
The answer is yes, as seen here.
The control, or long-chain triglyceride consuming group, is on the left and the MCT, or medium
chain triglyceride group, is on the right for the test group.
The T0 is the baseline, before the supplementation.
